Herinnering: Uitnodiging Zomer EM Bessenpluk festijn, zaterdag 13 juli 2019

Bessenplukdag zaterdag 13 juli

Goed nieuws: ondanks het bericht dat vorig jaar de laatste bessenplukdag zou zijn, kunnen we deze zomer gelukkig toch bessen plukken bij de biologische- en met EM geteelde Weldaad Bessengaard van Auke Vonk. Een feestje voor de hele familie.

U kunt rode, blauwe en kruisbessen plukken, maar er zullen ook al bramen en pruimen zijn. En een extra geluk: u betaalt slechts € 4,= per kilo (terwijl biologische besjes in de supermarkt € 20 tot € 28 euro kosten). Ook de EM-winkel is er met een stand vol EM-producten en geeft die dag 10% korting.

Openingstijden: 10:00 tot 17:00
Koningin Wilhelminalaan 6a
8384 GH Wilhelminaoord

How a healthy microbiome could supercharge the body’s natural cancer-fighting cells

How a healthy microbiome could supercharge the body’s natural cancer-fighting cells

Nick Lavars July 1st, 2019

The ways in which the communities of bacteria living within our bodies influence our overall well-being are becoming better understood all the time, and with that better understanding comes potential new ways to intervene for better health outcomes. Adding to this is a new discovery by researchers in Melbourne, who have described how a healthy microbiome can boost the activity of killer immune cells that are vital to fighting off infections and cancer.

A string of discoveries over the past few years alone have uncovered interesting links between the microbial communities that call the human body home and its overall health. These bunches of bacteria and the metabolites they produce have been linked to obesity-related depressionPTSD and Alzheimer’sdiabetes and autism, and a team of researchers at the University of Melbourne looked to expand on this by investigating their links with the immune system.

More specifically, they sought to learn how the microbiome can drive the development of memory T cells, which are immune cells that have evolved to quickly recognize dangerous pathogens that threaten the body and swiftly spring into action to kill them off.

“We were trying to understand how the microbes that live in and on us influence our ability to form killer memory cells,” associate professor Sammy Bedoui explains to New Atlas. “We addressed this question in preclinical mouse models, where we compared mice that did to those that did not have microbiota. We found that in the absence of microbiota, killer T cells failed to survive as memory cells. The reverse was true in mice with microbiota that we fed a high-fiber diet, akin to eating All-Bran or muesli. Here we found that more production of particular metabolites by the microbiota enhanced the ability of killer cells to survive and form memory cells.”

The metabolites in question are short-chain fatty acids (SCFAs), and the team found that these can infiltrate the body’s lymph nodes and spleen to influence the way the T cells use their energy, allowing them to sustain themselves for longer.

“These SCFAs change the way that the killer cells utilize fuels for energy generation,” Bedoui tells us. “More specifically, they allow the killer cells to reduce their reliance on sugar and instead allow them to burn fats. This is critical for their long-term survival. Cells that only rely on burning glucose fail to survive.”

Conveniently, the memory T cells that are aided by this healthier microbiota have shown great promise in cancer immunotherapy. This branch of cancer treatment and research focuses on supercharging the body’s own immune system to take the fight to the disease, with ramping up the activity of T cells a particularly promising avenue of attack.

Much of the research around microbiome and human health focuses specifically on gut bacteria (though other communities, such as that found on the skin, have also produced some interesting discoveries). Bedoui tells us they are yet to precisely pinpoint the origins of the beneficial SCFAs, though the signs point to the gut playing an important role.

“We have not formally distinguished whether our effects are solely mediated by the gut microbiome,” he says. “What points to it, however, is that the high-fiber diet has such a dramatic effect. So, we would suggest that the gut microbiome is critical, but it is also possible that the microbiome of other sites, like the skin, lungs, etc. may also play an additional role.”

Although this link has only been demonstrated in mouse models so far, the team describes the discovery as “very exciting” and is hopeful it can lead to new drugs that improve the effectiveness of cancer immunotherapies. The timeframe for the development of synthetic versions that replicate these effects is unclear, however.

“We are working on this at the moment,” says Bedoui. “It is too early to answer, but because we now understand the function of these naturally occurring substances, we can use this ‘functional fingerprint’ and test large collections of chemical compounds for their ability to induce similar changes.”

The research was published in the journal Immunity.

Source: University of Melbourne (PDF)

bron: https://newatlas.com/healthy-microbiome-natural-cancer-fighting-cells/60377/

Restoring missing gut bacteria a potential cure for food allergies

A study by a team of scientists from Boston Children’s Hospital and Brigham and Women’s Hospital suggests food allergies can be triggered in infants by a lack of certain gut bacteria. As well as identifying which bacteria in human subjects are key to protecting against the onset of food allergies, a subsequent mouse study revealed a specific probiotic cocktail can reverse pre-established allergies.

Over the last few decades rates of food allergies have been rapidly rising in Western industrialized nations. It is unclear exactly why this is happening but one of the more interesting hypotheses is that disruptions to a baby’s growing gut microbiome can trigger the onset of food allergies in infancy.

Investigating this hypothesis the new research first set out to examine the gut microbiome composition of a number of infants. The study followed 56 infants with food allergies and 98 infants without. Fecal samples were taken every few months, up to the age of 30 months.

“It’s very complicated to look at all of the microbes in the gut and make sense of what they may be doing in food allergy, but by using computational approaches, we were able to narrow in on a specific group of microbes that are associated with a protective effect,” explains Georg Gerber, co-first author on the new study.

Homing in on a specific handful of gut bacteria that were in lower abundance in those infants suffering from food allergies, a subsequent mouse study affirmed the allergic association. Mice sensitized to an egg allergen were found to be protected from allergic reactions when administered the specific cocktail of six bacterial species identified by the researchers.

Even more interesting was the finding that these specific bacterial cocktails completely suppressed allergic reactions in mice already sensitized to an allergen. This discovery implies that not only can allergies be prevented from developing in the first place, but a pre-existing allergic response can be reversed after it has already developed.

Talal Chatila, senior author on the study, says his team’s research affirms the microbiome is a fundamental mechanism in determining the development of food allergies in a person. Chatila also adds, “in adult mice that had become food-allergic, we could suppress their disease by introducing the good bacteria, which means to us there is the potential to treat somebody with established food allergy and reset their immune system in favor of tolerance.”

All of this, of course, needs to be proven in human subjects, but the researchers are already working towards several human clinical trials in both adults and infants. These trials will investigate fecal transplants targeting peanut allergies, as well as specifically generated probiotic mixes for pediatric food allergies.

Chatila ambitiously suggests there could be a product on the market stemming from this research within as little as five years. To achieve this Chatila, along with several other researchers on the project, founded a company called ConsortiaTX with the plan to create novel microbial therapies to treat allergies.

“When you can get down to a mechanistic understanding of what microbes, microbial products, and targets on the patient side are involved, not only are you doing great science, but it also opens up the opportunity for finding a better therapeutic and a better diagnostic approach to disease,” says Lynn Bry, co-senior author on the new study, and co-founder of ConsortiaTX. “With food allergies, this has given us a credible therapeutic that we can now take forward for patient care.”

The new study was published in Nature Medicine.

Brigham and Women’s Hospital, Boston Children’s Hospital

bron van het artikel: https://newatlas.com/gut-bacteria-microbiome-food-allergy/60309/

Phone-connected device detects bacterial toxins in water

Potentially fatal to both animals and humans, blue-green algae blooms occur when overly-abundant cyanobacteria in the water produce harmful substances known as cyanotoxins. The sooner those toxins are detected, the better – which is where a new smartphone-connected device comes into the picture.

Ordinarily, when officials are checking for the early signs of algae blooms in lakes or rivers, they take water samples that have to be sent off to a lab. By the time those samples have been analyzed, the bloom may have already reached the stage where the public should have been alerted.

Led by Asst. Prof. Qingshan Wei, scientists at North Carolina State University set out to make earlier warnings possible, producing what is being called the world’s first portable cyanotoxin-detection system. Users simply place a drop of water on a chip, which is then inserted into a reader device that is in turn mounted to a smartphone.

The chip is preloaded with single-stranded DNA (ssDNA) dyes combined with molecules known as aptamers. These bind with any target molecules that may be present in a sample, causing them to fluoresce. As a result, within just five minutes, an app on the phone is able to alert users to the presence and levels of four common types of cyanotoxins – anatoxin-a, cylindrospermopsin, nodularin and microcystin-LR.

The chip is preloaded with single-stranded DNA (ssDNA) dyes combined with molecules known as aptamers. These bind with any target molecules that may be present in a sample, causing them to fluoresce. As a result, within just five minutes, an app on the phone is able to alert users to the presence and levels of four common types of cyanotoxins – anatoxin-a, cylindrospermopsin, nodularin and microcystin-LR.

“Our technology is capable of detecting these toxins at the levels EPA [Environmental Protection Agency] laid out in its water quality criteria,” says Wei. “However, it’s important to note that our technology is not yet capable of detecting these cyanotoxins at levels as low as the World Health Organization’s drinking water limit. So, while this is a useful environmental monitoring tool, and can be used to assess recreational water quality, it is not yet viable for assessing drinking water safety.”

The researchers are now working on boosting the system’s sensitivity, so that it can be used to determine if water is safe to drink. They also state that if produced at a commercial scale, the reader device should be relatively inexpensive – it currently costs less than US$70 to manufacture, with the chips coming in at under a dollar each.

A paper on the research was recently published in the journal Analytical Chemistry.

Bron: North Carolina State University

bron: https://newatlas.com/portable-cyanotoxon-detection-device/60298/

Compost, food for thought

      Geen reacties op Compost, food for thought

Food for thought
Tossing the wilted kale you never got around to cooking may be a bigger contributor to climate change than throwing away a plastic takeout container. A recent study by Zero Waste Scotland found that the carbon footprint of home food waste is close to three times greater than that of plastic waste, largely because when food goes to the landfill it releases methane gas, which is even more damaging to the atmosphere than carbon dioxide.

Composting, which turns organic waste into fertilizer, is one solution to the food waste problem. Humans have been composting for as long as they have been farming. The first written reference (pdf) to compost dates to around the year 2300 BC. George Washington, the first US president and avowed gentleman farmer, spent a lot of time thinking—and writing—about compost at his Mount Vernon plantation.

But large-scale food waste collection and processing is expensive and requires participants to be diligent and well informed. Can cities get citizens to do their part or will the idea end up in the trash heap?

BY THE DIGITS
2 months: Time it takes for an apple core to decompose

450 years: Time it takes for a plastic water bottle to decompose, though plastics may never truly disappear

1.94 million: Tons of food composted in the US in 2014

29 million: Tons of food sent to landfills in the US in 2014

$1,500: Value of the food wasted each year by an average American family of four—that’s 2 million calories

2020: Year San Francisco plans to achieve zero waste

95%: Amount of food waste recycled in Seoul, South Korea today

1 billion: Number of people who could be fed on less than 25% of the food the US and Europe wastes

BREAKING IT DOWN
How composting works

While food scraps and other natural waste like dead leaves and lawn clippings will decompose on their own, composting creates optimal conditions to speed up the process. A good compost pile starts with the right mix of organic materials. The pile needs both nitrogen-rch “green” materials, like food scraps and manure, and carbon-dense “brown” materials, such as dry leaves and wood chips.

The scraps should also be small in size to maximize the surface area on which microorganisms can feast. A backyard compost pile is a mini ecosystem, with bacteria and fungi feeding on the organic matter; protozoa, nematodes, and mites feeding on the bacteria and fungi; and predatory nematodes, predatory mites, and other invertebrates feeding on the protozoa, nematodes, and mites.

A compost pile also needs moisture, either from rain or manual watering, and oxygen, which can be added by turning the pile regularly or installing aeration pipes. Lastly, the pile needs to be at least 140°F (60°C) to prevent rot.

Whether you make your own or buy commercially produced compost, the benefits (pdf) to your yard and the environment are myriad. Compost reduces the need for chemical fertilizers while adding nutrients to the soil, helping the soil retain moisture, and limiting erosion. And there’s evidence that healthy soil is crucial to addressing climate change.

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Emotional temperament in babies associated with specific gut bacteria species

Rich Haridy June 19th, 2019

A new study from the University of Turku has uncovered interesting associations between an infant’s gut microbiome composition at the age of 10 weeks, and the development of certain temperament traits at six months age. The research does not imply causation but instead adds to a compelling growing body of evidence connecting gut bacteria with mood and behavior.

It is still extraordinarily early days for many scientists investigating the broader role of the gut microbiome in humans. While some studies are revealing associations between mental health conditions such as depression or schizophrenia and the microbiome, these are only general correlations. Evidence on these intertwined connections between the gut and brain certainly suggest a fascinating bi-directional relationship, however, positive mental health is certainly not a simple a matter of taking a certain probiotic supplement.

Even less research is out there examining associations between the gut microbiome and behavior in infants. One 2015 study examined this relationship in toddlers aged between 18 and 27 months, but this new study set out to investigate the association at an even younger age. The hypothesis being, if the early months in a young life are so fundamental to neurodevelopment, and our gut bacteria is fundamentally linked with the brain, then our microbiome composition could be vital in the development of basic behavioral traits.

The study recruited 303 infants. A stool sample was collected and analyzed at the age of two and half months, and then at around six months of age the mothers completed a behavior questionnaire evaluating the child’s temperament. The most general finding was that greater microbial diversity equated with less fear reactivity and lower negative emotionality.

“It was interesting that, for example, the Bifidobacterium genus including several lactic acid bacteria was associated with higher positive emotions in infants,” says Anna Aatsinki, one of the lead authors on the study. “Positive emotionality is the tendency to experience and express happiness and delight, and it can also be a sign of an extrovert personality later in life.”

On a more granular level the study homed in on several specific associations between certain bacterial genera and infant temperaments. High abundance of Bifidobacterium and Streptococcus, and low levels of Atopobium, were associated with positive emotionality. Negative emotionality was associated with Erwinia, Rothia and Serratia bacteria. Fear reactivity in particular was found to be specifically associated with an increased abundance of Peptinophilus and Atopobium bacteria.

The researchers are incredibly clear these findings are merely associational observations and no causal connection is suggested. These kinds of correlational studies are simply the first step, pointing the way to future research better equipped to investigate the underlying mechanisms that could be generating these associations.

“Although we discovered connections between diversity and temperament traits, it is not certain whether early microbial diversity affects disease risk later in life,” says Aatsinki. “It is also unclear what are the exact mechanisms behind the association. This is why we need follow-up studies as well as a closer examination of metabolites produced by the microbes.”

The new study was published in the journal Brain, Behavior, and Immunity.

Source: University of Turku

Lees het hele artikel hier: https://newatlas.com/gut-bacteria-microbiome-baby-infant-behavior-mood/60197/

Nieuw: Vijver-pakket om met EM de vijver natuurlijk schoon te maken en schoon te houden

De EMwinkel.nl is begaan met de balans en de gezondheid van onze vijvers; zij hebben hiertoe een mooi initiatief genomen: er zijn complete EM Vijver-pakketten samengesteld om met EM het natuurlijk evenwicht in vijvers te kunnen herstellen.

In het voorjaar vullen vijvers zich vaak met algen. De algen geven aan dat de natuurlijke balans in het water hersteld moet worden. Effectieve Micro-organismen zijn bij uitstek in staat om het natuurlijk evenwicht te herstellen. Omdat het niet altijd even eenvoudig is om er achter te komen welke EM-produkten je nodig hebt en in welke hoeveelheden, zijn er 3 verschillende pakketten samengesteld op basis van oppervlakte: tot respectievelijk 10, 20 en 30 m2.

Aanlegplaatsen voor micro-organismen
De pakketten bevatten de volgende EM produkten: EM Vijver, EM Bokashi ballen, Microferm, Zeeschelpenkalk, Bokashi strooisel en EM-X keramiek pijpjes.

  • EM Vijver is een variant van EM-Actief die veel specifieke micro-organismen bevat, vooral veel meer fototrope bacteriën.
  • EM Bokashi ballen. Deze bevatten de Effectieve Microorganismen, klei, EM-X keramiek en organisch materiaal en worden over de bodem van de vijver verspreid, 1 per m2. Op deze plakken ontstaan in de bodem van de vijver koloniën van positieve micro-organismen die zich verder over de bodem verspreiden.
  • Microferm. Deze toevoeging van EM-Actief aan het water zorgt gelijk voor een verbetering van het natuurlijk evenwicht in het water vanwege de enorme aantallen positieve micro-organismen. Dit kan het beste gedoseerd toegepast worden (1 liter op 10.000 liter water).
  • EM-X keramiek pijpjes. Deze netjes kunnen in de vijver gehangen worden ter verbetering van de waterkwaliteit. Het is nog beter om ze in een waterpomp te plaatsen zodat het water zoveel mogelijk met het keramiek in contact komt.
  • Bokashi strooisel. EM-Bokashi werd, voordat EM-keramiek op de markt kwam, gebruikt als een soort aanlegplaats voor micro-organismen. Men gebruikte een net met nauwe mazen of een zak om de EM Bokashi in het water te hangen. Voor een beperkte tijd zijn dat ideale plaatsen voor de Effectieve Micro-organismen die aan het water worden toegediend. Ze vermeerderen zich daar en de nieuwe micro-organismen worden voortdurend aan de omgeving afgegeven, waar ze hun zuiverende werking kunnen uitoefenen. Daarnaast wordt het water steeds voorzien van anti-oxidanten en andere gezonde stoffen.
  • De zeeschelpenkalk wordt toegepast tegen blauwalg overlast of ter voorkoming hiervan. Kalk buffert en laat het Fosfaat neerslaan op de bodem. Heeft u last van groenalg dan geen zeeschelpenkalk gebruiken. Stro is wel goed te gebruiken bij groenalg.

meer info op EMwinkel.nl: het EM-vijver-pakket